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Tadalafil (Latin Tadalafil) - medication for the treatment of erectile dysfunction (inability to attain or maintain an erection necessary for sexual intercourse). Included in the group "Preparations for the treatment of erectile dysfunction."

Tadalafil is effective, reversible, selective inhibitor of specific phosphodiesterase type 5 (PDE5) cyclic guanosine monophosphate (cGMP). When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 tadalafil leads to increased levels of cGMP in the cavernous body of penis. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis, causing erection. Tadalafil has no effect in the absence of sexual stimulation.

Cialis improves erection and the possibility of successful sexual intercourse. The drug acts within 36 hours. The effect is manifested as little as 16 minutes after taking the drug in the presence of sexual arousal.

Tadalafil in healthy individuals does not cause significant changes in systolic and diastolic blood pressure compared with placebo in the supine position (mean maximum decrease of 1, 6 / 0, 8 mm Hg. Art., Respectively) and in the standing position (mean maximum decrease of 0, 2 / 4, 6 mm Hg. Art., respectively).