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"Loop" diuretics, is fast approaching, a strong and transient diuresis. It has a natriuretic and hlorureticheskim effects, increases the excretion of K, Ca2, Mg2. Getting into the lumen of the renal tubule in the thick ascending segment of the tribe of the loop of Henle, blocking reabsorption of Na and Cl-. Due to increased allocation of Na occurs secondary (indirect osmotically bound water) increased the excretion of water and increase the secretion of K in the distal renal tubule. Simultaneously, the excretion of Ca2 and Mg2. It has a secondary effect resulting from the release of neurotransmitters and intrarenal redistribution of intrarenal blood flow. Against the backdrop of a course of treatment is no weakening effect. In heart failure will quickly lead to a reduction of preload on the heart through the expansion of large veins. It has a hypotensive effect due to increased excretion of NaCl and reduction reactions of vascular smooth muscle to vasoconstrictor effects and by reducing the BCC. Effect of furosemide after i / v injection occurs within 5-10 min after oral administration - within 30-60 minutes, a maximum of - 1-2 hours, duration of effect - 2-3 hours (with reduced kidney function - up to 8 hours) . During the period of excretion of Na increases significantly, but after the termination of the elimination rate is reduced below the initial level (the syndrome of "bounce" or "cancel"). The phenomenon is caused by a sharp activation of the renin-angiotensin and other antinatriuretic neurohumoral regulation of the units in response to the massive diuresis, stimulates arginine vazopressivnuyu and sympathetic systems. Reduces the incidence of atrial natriuretic factor in plasma, causes vasoconstriction. Due to the phenomenon of "rebound" when taking a time per day can not have a significant impact on the daily excretion of Na and BP.