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Antidepressant. Refers to a group of selective serotonin reuptake inhibitors. The mechanism of action of Paxil is based on its ability to selectively block the reuptake of serotonin (5-hydroxytryptamine / 5-HT /) presynaptic membrane, what has caused this increase of free content neurotransmitter in the synaptic cleft and increased serotonergic action in the CNS responsible for the development timoanalepticheskogo (an antidepressant) the effect. Paroxetine has low affinity for the m-cholinergic receptors (anticholinergic action has the weak), a1-, a2-and b-adrenoceptors, as well as dopamine (D2), 5HT1-like, 5HT2-like and histamine H1-receptors. According to the study of behavior and EEG of paroxetine revealed weak activating properties when it is administered in doses higher than those required for inhibition of serotonin reuptake. Paroxetine does not affect the cardiovascular system, does not affect psychomotor function, does not inhibit the central nervous system. In healthy volunteers, it does not cause a significant change in blood pressure, heart rate and EEG. The main components of the profile of psychotropic activity of Paxil antidepressant and are protivotrevozhnoe action. Paroxetine may cause weak activating effects at doses exceeding those required for inhibition of serotonin reuptake.